the only issue with Construct compared to GMS2 or Unity (2D) is yes the export is not native but rather a web wrapper around your game. It's basically a version of Chrome for your game. Does the player know? Doubtful. Performance is probably the only thing that would make you (the dev) notice it. I doubt a player would ever know. But I've built things side by side with GMS2 and Construct with the same assets and I can tell the difference of GMS2's export, its just better, I don't know how to describe it.
However, all that said, Construct is an amazing prototype tool. It's ridiculously fast. So many corners are cut for you that any engine I work with I'm always wishing for the ease of Construct. When I first got into to GMS2 I couldn't believe how much I had to do myself..although GMS2 has other pluses, but C3 is all about speed.
I hate the subscription model, it's a big turn off for everyone I talk to about it. But I use it a lot so it's worth it for me. When people ask me if it's worth it I always ask them: will you use it as much as you use Hulu? because its the same price. If yes, then there's your answer!