Sub Layouts - When making an RPG or sidescroller with many layouts, it'd be helpful to have sub-layouts where everything is still retained once the player teleports to them. They can be used for small rooms or little sections like you see in many old RPGs. This way all the private variables are retained and if you exit the room, the events which took place will still be there and not reset.
Making sense? I'll elaborate if you want.
Encryption - This way one will be more confident with creating an external file which handles save slots or inventory items.
Integration of Python exclusive features - If I'm not mistaken, there are some features which can only be utilized through Python. It'd be nice to see these made into events.
Online focus - Who doesn't love online integration? I know a user did a good job at making online work through Python, but making an official plugin will be the next logical step.
AI behaviour? - This can be a distant consideration, but maybe creating an AI behaviour that performs simple tasks as chase down a character or try to avoid a character once it's approaching? Probably won't work since it's an abstract concept but it can be at least considered.
A dialogue system - I created one months ago which handles standard dialogue along with options and responses based on the options chosed. Even emoticons were supported by simply adding something like #H at the end of the dialogue string. It's all Python driven and was pretty messy (I had just started learning Python) but I'll probably try remaking it now into something more understandable and powerful. Anyone interested?