Errors are happening in r46.
After some effort I was able to get some error messages:
<img src="http://www.fileden.com/files/2008/3/4/1796632//error2.JPG" border="0" />
<img src="http://www.fileden.com/files/2008/3/4/1796632//error.JPG" border="0" />
Typically, I copy/paste some sprites in the layout and attempt to save. 75% of the time while trying to save, C2 crashes. If I press ctrl+s, sometimes it closes without an error message. This is when the bug began to happen. I was just pasting some of the mushroom sprites and rotating/scaling them in the layout.