It's not possible.
Why do you need to do this?
You can use a global variable to store data between layouts. So when you switch to the second layout, check the value in the global variable and update the sprite if needed.
For example: Im start in Layout called 'Town' in this map you can't have interaction with Town governor NPC, because his instance variable 'Dialogue' is 0 at start (should be 1 to take action)
When i leave this map, to other Layout map called 'Village' here i can have interaction with other NPC, after that interaction - NPC Governor should have changed instance variable 'Dialogue' to 1 and now posibility to talk/ do action
I know i can make with Global variable, but for all NPC's in future ? ;/
i already have lot Global variables in game ( its RPG game, so lot of statistics)
Is there no other option than setting everything in Global variable?