Some things to keep in mind:
Web performance is not as good as native EXE performance. With webGL accelleration, it gets close, but still you may need to tone down the game slightly.
C2 does not have any shaders at the moment, mainly because webGL is only supported in Chrome and Firefox.
Other than these two main points, you should be fine. I haven't used MMF2 but I am 100% confident that C2 is much superior.