on my pc:
Intel Core i7-3770k 3.500GHz, 32GB RAM, Geforce GTX 780 it behaves all the same on every possible resolution setup with fullscreen on / off.
Game stays at 59-60 fps when not moving or moving very slowly (pressing arrow keys from time to time) - here it's fine, nice, smooth and all
but if I start moving around (hold arrow keys) game drops down a bit and stays between 56-58 fps and it's not nice to play anymore. Basically it looks like watching a movie from very old and scratched dvd disc. Keeps pausing for a friction of a second every 2 seconds. I did not noticed any input lag or other issues, only these regular janks when fps drops below 59.
Could you provide similar test game but exported with NW.js ? just to compare if it's the same behavior.
EDIT: Tested in chrome 40.0.2214.115m (64-bit) on Windows 8.1 64