"big" is an obscure term. What does big mean? 1000 levels? 5000 different assets? Only 10 levels but the layouts are gargantuan? What does big mean for your project?
I´m not sure if there is some technical limitation in terms of size. If your project is so big that you get concerned about if Construct can even handle it, maybe your project is too big period, at least for a solo-developer. I´ve seen very few cases of solo-devs making big games and not going insane :)