Yes, I have tried it before. It is simple solution for control, collision and shadow casting. But The "problem" is attaching the sprites to this objects without rescaling those too. Even if you get this done, I think it is quite tedious to edit a scene in construct, because you don�t see the scaling effect until preview. Even the mouse proiection is changed.
Another quick alternative is to use the "military" projection. We can view this in games like Ultima Online and Nox. The base is a top view. More info here: http://www.compuphase.com/axometr.htm.
But I would like to know a modular solution for doing any kind of parallel projection