it work's fine for me, 2x2 sprite (empty or with some colours) then resized to something bigger and then make 1:1 - work's well.
edit: no wait. when you create a new sprite - no colours, set size to 2x2 and save, you cannot select it in layout, but when you fill it with some colour and make 1:1 it gonna be visible and fixed.
edit2 lol: but it happens to me only couple of times, usually works fine