will not succeed in smooth transitions from one animation to another
Not entirely wrong but also not entirely true. You can draw transition animations if you want to.
Also, your game will take up more memory at times
True, but in this day and age it pretty much doesn´t matter. Every phone has gigabytes of space and people also happily download a game even if it´s 500mb (like the game you posted has almost 500mb)
And since because you said it cannot be done with the same quality in Construct... observe:
And yes this is made in Construct.