I have to be so bold to disagree. I found the experience in my low resolution retro project so jarringly bad with pixel rounding activated, that in conclusion it simply cannot be used. And I've seen posts from other users who also find it unusable for their pixel endeavors.
I may be wrong but I think developers for old platforms like the SNES designed their way around this. As in making sure their game objects moved by increments that played nice with a low-resolution pixel grid. No 'move sprite by 0.635 pixels per screen draw' for instance. They also had the luxury of working with platforms that gave you a consistent screen update at all times, which made delta-timing unnecessary. No need to compensate for different hardware speeds, and no Windows lurking in the background to hog resources with page filing and indexing and whatever it is it does.