I know what you're coming from because i was in your very same situation nearly 2 years ago. I'm working on a huge project, which is not even a game to be honest, it's an eco-system sim, like the old simlife, but with a survival simulation built-in, with ridiculous complex survival mechanics (stuff like proteins in your blood, liquid lost by sweating and so on). The game needs to track thousand objects on a huge single map (that can be resized at new game) as well as the character variables (at least 50 object variables...). Recently, with the big V-sync issues coming from Chrome, the game used to jerk sometimes, but the situation is getting better and better at every new version, and it is now nearly ABSENT in NW.js (as latest alpha 12), and i suspect it will get even better. The game runs just fine on my low-mid PC.
Also, i want to point out C2 is truly a freaking awesome piece of software: devving with it is like a hot knife cutting butter, and me and my team wouldn't be able to work on our dream-game without it, even with high programming skills and Unity.
So, by all means go on!