The Binding of Isaac has a "poopy" art direction, kind of on purpose.
The gameplay though is pretty deep, and offers hours upon hours of gameplay and replay value.
Every run is different and offers you possible builds to change the capacities of your character according to the item you get in loot.
And the story/narration is provided through items and cut-scenes that are open to interpretation, nothing to read much.
Also, the type of game is actually different. BOI is a rogue-like, hence the replay value to it.
I'm not familiar with Tower 57, but it does not look more than a twinstick shooter, with a nice pixel-art look to it.
According to the reviews, everybody loves the graphic look, but seems to find the arena-fight mechanic to not fit with it somehow.
Also people encountered bugs.
It might be only a question of taste in the end, and luck, if you haven't encountered bugs. Nevertheless, BOI has been around for years, and not buggy.
The looks of it possibly does not appeal to you, but its depths in terms of controls/gameplay/design makes it memorable.
Tower 57 seems to have nice looking graphics for it. But that looks like a basic shooter to play.
Aesthetics might not be the most important aspect of a game; gameplay is.
Perhaps you can look into Nuclear Throne if you like pixels and arena shooters.
It is another indy darling I wasn't too found of but which had some following and made its mark in time.