Adobe Flash
Bone-based: no
Key frame concept: yes
Sprite sheet rendering: no
OS: ?
Anime Studio software is used mainly for cartoons drawing.
Bone-based: yes
Key frame concept: ?
Sprite sheet rendering: no
OS: Win, Mac
ProMotion software is used for drawing of a detailed and pixel precise graphics. cosmigo.com/promotion/index.php
Bone-based: no
Key frame concept: no
Sprite sheet rendering: no
OS: ?
GraphicsGale is a simple raster animation editor for .gif and .avi animations. humanbalance.net/gale/us
Bone-based: no
Key frame concept: no
Sprite sheet rendering: no
OS: Win
ASE (Allegro Sprite Editor) is a pixel art raster sprite editor. aseprite.org
Bone-based: no
Key frame concept: no
Sprite sheet rendering: ?
OS: ?
Anatomy is sprite animation software for 2D game development. spritetools.com
Bone-based: yes
Key frame concept: yes
Sprite sheet rendering: yes
OS: all
List of drag and drop sprite sheets creators that use another sprite sheets or frames:
Zwoptex, $15 zwopple.com/zwoptex
Predator, $15 spritesheeteditor.com
Simple sprite editor sourceforge.net/projects/simplespriteedi
list of 2D Map rendering software:
Dungeon Crafter - is a small freeware program that lets you lay down walls, floors, doors, and objects. ww2.dungeoncrafter.com
Tile Studio - Tile Studio is a complete development utility for graphics of tile-based games. tilestudio.sourceforge.net
Tiled Map Editor is another free map editor. mapeditor.org
Good luck