For all those who have AMD GPU cards, the problem may be with the Catalyst Pro Control Center software feature HydraVision.
I was having the same problem with C2 crashing and not closing both on my Windows 7 computer and my Windows 8. They both have AMD video cards and run CCC with multiple monitor connectioned. I took the approach that Ashley is correct in that it is the video card drivers. I made sure that I had the latest drivers from AMD, but the problem persisted. After lots of research I found that both Windows 7 & 8 have had problems with the ATI Catalyst Control Center software component called Hydravision that affects people using several GPU intensive programs like Photoshop and Inkscape and I found Construct 2 also. The solution was to turn off HydraVision in the Catalyst Control Center Software. One person suggested uninstalling HydraVision software completely. I turned it off on my Win 8 machine and all the crashing stopped. It had gotten so bad that every few minutes I got a crash the more my project grew in size with more images/sprites.
My Win 8 machine has a AMD FirePro W5000 with 2gigs ram and 3 different size monitors connected. I have not tested the Win 7 machine lately. I will post results when I do.
The HydraVision feature is used to divided a monitor into multiple Desktops. I really don't need that feature,so having it turned off does not cause me a heartache at this time. AMD states that Win 8.1 should solve the problem with the CCC HydraVision feature when it is released. Hope this helps some of you with your crash problems.