Yeah the same as the what "BobOfAMillion"
If you are not using tilesheets do so, just look up tilesheets on google images and you will see that there one image with lots of different ones inside of it, this means the computer only has to load up one image, also its much easier to make as you don't have to keep switching documents, just do it all in one.
When making tile sheets make sure you have a set size, for example for pixel art you would do something like 16x16, for yours it would be much bigger, then when in construct adding tile map make sure its set right in the proprieties to your size then you can just simply paint you level out with out worrying about the right spacing between each image.
Good Luck!!!