Have you tried disabling groups of events? Within my game, there are quite a bit of collisions for one object onto another, and making a family isn't really an option since each enemy is worth a different amount regarding score.
So If I've got 15 Collisions for Sprite1 and 15 Collisions for Sprite 2.
Sprite1 Collision Events should ONLY be Active when Sprite1 is on screen and when Sprite1 is off-screen the group of collisions is Inactive. Same rules apply to Sprite2.