I think based on your game it might be best to give Layout 2 its own event sheet and include 'main' where main has all of the general gameplay logic. I don't know what your plan is with the game, if you have lots of levels across different layouts then you can assign each layout its own event sheet and just include 'main' which will have all of the general logic. For example, anything to do with that specific level that is for spawning items, level gameplay, switches, doors, anything like that can be in a level specific event sheet. This is just for organisation though, like classes in programming. You can just have one event sheet for the entire game if you want and split everything into groups.