Yes, you even quoted where I described the case, any system that needs to check collision against many instances will run very badly without collision cells as they have to loop over each instance which can quickly go up to thousand and thousands of checks per tick, for example 128*128 = 16.384.
I wrote this after I tried rewriting a system in js with the intention to increase performance, but instead I actually made performance way worse as I couldn't use collision cells. Sure I guess I could create my own system, but it feels redundant if there is already one in the engine that also already has its own overhead of being created and updated.
I'm not sure you are aware, but behaviors and is overlapping on collision events make use of collision cells (unless you pick beforehand). It's just that js doesn't allow accessing the build in collision cells.