Actually, it is a bit unclear in the manual. I had to do a little experiment to find out.
Basically, if you have BOTH high dpi support AND high quality scaling enabled, games will render at native resolution if the browser they run in is 'zoomed'.
For example, you can 'zoom' into a page in chrome or firefox, which will scale all the page elements up. I imagine that high-dpi devices generally have their browsers default to high zoom settings.
There should be a more technical explanation of this in the manual. It could be helpful/hurtful on normal devices as well, assuming a zoomed browser window.