One thing I think would be cool to design, is your simple walkmesh with a 3D character to run about on over the 2D background, as in like, late-nineties Final Fantasy games. But that could be faked with 2D... and doing any of it requires artistic ability, some modeling knowledge, and it seems programs like Construct are created to be used by people who don't know anything, so they can do whatever without trying. Err, what am I saying? I don't know. It's all good.