Hello! I'm newish to construct, but this is what I would do: have an object that is centered to your viewport spawn them on the start of the layout. That way you have their position the same every layout. I don't know if this is your issue but I hope it helps!
Thank you for the fast reply. Sorry I forgot to mention this before, but the sprites are capable of moving to any area within the layout. My problem is how to translate the X, and Y locations of these sprites to new layouts of different sizes similar to what they were in the original layout.