Well, my NPCs aren't just gonna stay in one layout for I want them to act more realistic than just stand in one spot or move around in a map for the rest of the game. I know indeed that RPGs have not been made in Construct yet thats why I'm starting to make one. If I don make one successfully, I would probably boost the interest of others in using Construct.
BTW, when a game in Construct is running, and that a layout is being played, are other layouts running too? or just on pause or standby or something.
If my NPCs were to travel between layouts, I would probably need a RealTime system or something to monitor them all.