Memory usage is depending for images.
If you use cloned sprites (duplicated frames) may take double memory usage.
If you use bigger images may increase memory usage.
If your canvas is upscaled than fixed windows, it adds more memory.
You should design your workflow to keep good memory usage for reducing and reciclying animation frames, small images, one sprite for all animations states, composing scene with props with different properties like opacity, size, angle, etc.
Otherwise, if you plan to have million of animations, Spriter is solution.