I just had an idea for a game, maybe it already exists in some form, where the main focus is on emptying an inventory.
Picture this...it's rather text based where you don't see battles but rather the aftermath only (or possibly by turn) and you select options after doing the inventory sorting.
Each member of the party has an inventory and your main goal is to keep it with free slots or you lose. So at the end of battles they will randomly pick up loot, boss battles are worse to come across as they pick up more loot. You then get a chance to clear it out before continuing. There will be certain techniques you can use to clear items.
Crafting - a random character can build items from a combination of smaller items clearing slots. Potions - a random character can combine potions you pick up to make more powerful potions and clear slots too. Something where the character will not automatically pick up loot could be a useful skill.
Obviously as well as the inventory the items are important. They can be used automatically in battles by your chars. Potions and consumables can be kept to be used in battles, but at what cost? Oh yeah, it fills up your inventory.
You can also equip items to characters to keep them out of the inventory and discard old ones.
There would be upgrades along the way. Inventory can be made bigger etc.
I think it would be fun because things like storing items, boss battle endings and random chests become bad things. Getting rid of as many items as you can (while tactically keeping some in the inventory) becomes more important. Also I really want a chance to have the item that fills your inventory and ends the game have a pop up, you've been killed by BREAD.