I think you're on a newer version of Construct than I am, so your .cap won't load for me, but have you checked to make sure your layer isn't set for Linear Sampling? Even if the application is set to Point Sampling, try setting that one layer to Point as well, just to make sure.
Also, I've occasionally noticed some blurriness when using transitions, so see if turning off any transitions between the previous layout and that one makes a difference of any kind.