Several options:
1. Use Button object and style it with CSS. But this is not a good choice for many games, because HTML elements are rendered above the canvas (or will require a special HTML layer), can "steal" mouse focus and have a few other annoying quirks.
2. Use a sprite with several frames or animations. If mouse cursor over the sprite -> Set frame 1, Else set frame 0. On sprite clicked -> Set animation "clicked" and so on.
3. Use an addon like ProUI. (also not recommended unless you require lots of other UI controls)