Maybe there's confusion about the thread linked:, that thread is about nwjs, which is an EXE version of a html5 games, usually would find these to be distributed via steam - steam having a paid entry fee and someone who attempted to upload a malicious game would lose money and be banned for ever attempting that, never once heard of it happening, so that's the reassuring case for an EXE downloadable html5 game.
If someone, even an adult, downloads an exe from a friend or unusual website, and they aren't familiar with computers, always used admin account, AND it happened to be an extremely new malicious method that Microsoft haven't seen before (Where Microsoft have dedicated team who are extremely vigilent about updating Windows defender regularly), then yeah they may have their computer compromised.
A html5 game in the Web browser, like oosyrag mentions, is safe, a lot safer than an exe file, Web browsers have many manny protections in place, many restrictions (cannot run exe from html5 Web browser game).