Can be done Forge of Empires is a medium-heavy-server based game, when we talk about supporting thousands/hundreds of thousands/millions of players.
For a small scale version should be possible using only Construct knowledge, however for same scale support as FoE, it will require atleast some knowledge about Apis and Microservices and services like MongoDB and Mongoose in order to scale it up.
I'd say scalability is the only downside on Construct in this scenario, cause requires a bit more than Construct knowledge.
But if you have the knowledge i can't see any reason not to be possible.