This is pretty easy to test, just use the Advanced Random behavior to update the seed, then save (either using the debug save option or the plugin) close the game, then load the save.
If you look in the debugger, the PRNG Seed is no longer whatever you updated it to be using Advanced Random. This of course ends up affecting everything that is tied to random generation.
Now, I could get around this pretty easily by just updating the seed again after a load, but previously I didn't need to do this, and I am worried it could create issues if you save/load at just the wrong time. Am I actually just missing something and this is always how it worked and I've broken something elsewhere?