I think it's just better practice in general to aim for small apk sizes. Lots of people will cancel download if it's greater than 50mb (I'm pretty sure Flappy Bird is less than 1 mb!).
Yeah, if we talking about the game like flappy bird, but if you want to make isometric rpg with tons of weapons, armor, mobs, locations, and other head exploding stuff it's gonna be larger than 50mb for sure. But you right, even if 50mb limit will be raised, or anything else will happen, we still have a lot of other problems, like memory management and other.
I don't know if it will be a good advice, but another way is to target IOS platform )
And what of it? It has no upload limit? I heard appstore has 50-60mb too.