You could create a "Loader layout" that will be the first layout of your project that will do the following:
[On start of layout] Load game
[On load failed] Go to 'TitleLayout' (if you play for the first time)
Also, if you save in GameLayout loading the game will bring you to that layout, but I am sure you want to make it start from the Title screen so add this condition to every eventsheet:
[On load complete] go to 'TitleLayout'
In this way you can save anywhere at anytime, just remember not to set that condition to the TitleLayout event sheet