I was wondering if when I set things such as a variable value, is it less burden on the CPU if I use an expression to check another value or a condition?
It doesn't matter. The only thing the cpu has to worry about is how many operations it has to carry out each tick.
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Like Newt said, it's really not going to make any difference at all. Check out this post from Ashley if you haven't already. https://www.scirra.com/blog/83/optimisa ... -your-time
I actually have to be careful with my events in mine because they can drop the FPS to 20 if they are done wrong.
EDIT: When done right, my game can run around 55-59 FPS during normal circumstances of an action-heavy area.
That sounds like some kind of looping issue. It would be interesting to see the code you're using to get 20 FPS vs 55-59 FPS.
It's because I have a million things going on at once and need to order conditions very precisely or too much needless crap is being processed at once.