Construct2 should definitely be able to handle it.
As a WebOS user first and Android user second, I haven't yet felt the need to use CocoonJS/DirectCanvas. But from what I can tell, Phonegap adds very little overhead.
An HTML5 based ebook/children's book should definitely be possible and has, in fact, been done multiple times already (Kindle Format 8).
As for native toolsets. I'd recommend either Gideros (there's a children's book about a small blue elephant featured right on their homepage) or Haxe NME.
Gideros already comes with it's own IDE and Haxe NME supports plenty of other exciting platforms from the get-go.