I got this Idea from the Zbrush GUV feature that automatically unwraps 3d models for you so you can map textures for them.
GUV picture
Great for new users who do not want to learn UV mapping... Bad for any human who wants to try editing the texture later, because, it is only machine readable.
Well, I was thinking that people who want to just ripp off a tile set, would be discouraged if the tile set was scrambled. maybe a plugin can make the sprite into a matrix, and upon export matrix gets sequence scrambled, and a key to re-construct the matrix is saved.
After the game loads, have the game engine or plugin re-construct the matrix into the sprite bitmap.
I am sure, the day after release, some kid will just make some ripping utility to prove their script kiddy might.
But for the casual, slacker, game developer, who wants to rip off someone tileset, they will probably just look in their web browser cache for the tileset.
After seeing just a huge gob of pixel-ized noise, they will probably just give up.
I thought I would mention it here rather than the plugin section, because it might be a feature that brings in sales.
Anyone who has had their art ripped off, or defaced would flock to this feature I would think.
Sorry for the long post. :)