You're going to have to provide more details to get help. We need to know what kinds of things your game is implementing. A Capx file would be even better.
As far as I know, there aren't any documented issues with Node. I haven't had a single issue while developing my current game with the newest stable release of Construct 2.
I could only take a guess that it's a computer related issue or something that happens within your instructions that cause it to lag.