Not sure if anyone gets this or not, but i had this problem for the longest time and forget to report it. Every time i launch a preview of my game in chrome, it will only activate my controller when i press the x,y,b,a. Doesn't work with the dpad, until i press any of the x,y,b,a buttons. It's a 360 controller. Windows 7 64bit.
It's nothing major, just a weird quirk i always get in chrome.