We will need more specifics if you want actual examples...
Do you mean a sprite object is touching another sprite object? Yes, easy use isoverlapping condition or oncollision condition.
Do you mean mouse pointer or touch is overlapping sprite object? Yes, easy; incluse the mouse/touch object in project and use their over sprite object events.
Do you mean is touching both sprite objects in a certain order? Yes, easy you would just need to use variables.
Pretty much everything you can do in scripting you can do in construct2.