szymek I think that specific bug has been mostly fixed but Chrome still suffers from shocking vsync issues below 60fps. As well as NW issues that are preventing deployment to mac and linux. I think Ashley is slightly understating the third party issues.
[I will insert here that I have no experience with app development so anything I say may not apply in the mobile marketplace, where commercial-scale games can be a lot smaller and simpler]
As I've said before, If Scirra want to continue with a small number of staff then one exporter is really the way to go from their perspective. Otherwise it's a maintenance nightmare. Maintaining parallel codebases is absolutely horrible, but there's a reason GM and Unity do it.
Basically, from my perspective as a commercial developer, I can't afford to rely on so many third parties. Ashley made a valid point that you'll always be relying on third parties to some extent. However I'd rather rely on the 550 Unity employees. The difference isn't the reliance on third parties, it's who can afford to take responsibility. For example, if Unity runs badly on, say, PS4, or NVIDIA GPU's, Unity can take responsibility for that and fix it themselves. Ashley on the other hand cannot afford to take responsibility for this sort of stuff, and hence the engine is in HTML5, which takes the burden off of him and puts it on Google or whoever. The problem comes when Google or Apple or a mobile wrapper developer doesn't want to prioritize getting large-scale games to work correctly, due to the tiny portion of their userbase developing games like that.
I don't mean this as a slight to C2. It's without a doubt one of the best 2D engines out there for hobbyist/learning developers. But in my opinion it's not ready for commercial scale development due to reliance on third parties. [AGAIN, I'M TALKING PC/CONSOLES HERE] Not that it can't be done, but it can turn into a nightmare very fast when you want to release your game but for some unknown reason it janks on supercomputers, or runs horribly bad on all intel processors, or doesn't run at all on current-gen consoles.
tl;dr: HTML5 is the best choice for C2 but it means commercial PC developers will have a bad time.