I sometimes need to work on a huge project (over 8GB). Most of it are videos, but there are also tons of large images. Opening the project takes over a minute, and rendering spritesheets for the first preview about two minutes. But after that it works and runs fine, and the preview starts instantly (unless I change the graphics, then it needs to re-generate the spritesheets again). My specs: RYZEN 9 4900H/RTX2060, 24GB RAM.
You don't need two 16GB video cards, what you need is optimize the layouts where memory usage is excessive.