i was about to post the same, every time i do a debug i have to disable the camera,
i always get it after some errors of none existing sprites you have to click away
( i think otherwise you dont get it , not shure)
then it runs completly normal, but you dont see any objects
if i check in debug, these seem strange to me
scroll location are -1.$,-1.$
and mouse -1,-1
i suppose it has to do with this location thats been set
ps: i read the prev. post better, it looks like when the focus is out of the game window, it happens