Pixel-perfect rendering is only guaranteed if you use the 'Optimize for pixel art' project settings, as described in the manual.
Yes, but:
- Pixel rounding is undesirable in most cases, it makes movement jerky and causes headaches over prolonged sessions of play
- Letterbox integer scale gives black bars no one likes, ever
- Low fullscreen quality prevents smooth camera movement, causes headaches similar to pixel rounding
I asked for a solution for literal years, my plea was ignored, and now I made my own! I hope you like it !!
Like, 
Ashley, if you look at pixel games made in construct, a lot of people do not use those settings you mentioned, they prefer to take the rendering errors than to use them.