Using an instance variable on the spawner object, something along the lines of :
Pick a random instance of spawner, where instance variable is not set to 0 (default/empty), set var to 1.
Repeat this for 2, 3 and 4. You can use a for loop for 1 to 4 and use loopindex as the variable which will be 1,2,3,4 or just add 4 events top to bottom and they would run in sequence.
Then you have 4 spawners each randomly set to 1, 2, 3, 4.
Add logic to make 1 relate to a particular item, 2 is another item etc
Or if the item names are known and its easier with text, set the instance variable to a string and say where instance variable is blank/"", pick a random instance of spawner and set to item1name etc and repeat 3 more times.