Modern desktops with dedicated GPU's generally have have 4-8 GB of vram. Mobile devices don't have dedicated VRAM, but I'd say they generally also have 2-4 GB avavilable. If you don't go nuts with huge levels with thousands of unique sprites, or giant sprites that span areas larger than your viewport regularly, you're going to be fine. Long animations can also be a source of heavy VRAM usage.
If you see your estimated VRAM usage going up over 1GB, then you might want to reconsider your approach and think about optimizing.