What tools would you need? The only thing I can think of is maybe an isometric version of the tilemap object. Otherwise you can use a grid to pace sprites.
A lot of the motion behaviors can be used well enough from an isometric view. For motion more aligned to the iso view you can utilize a bit of math.
For the visual sorting it can be simple is all objects are the same size and cubes. For other shapes it gets more complicated and can yield unsortable cases.
I think overall any engine that can draw images can do isometric.