Make only a selected portion of a Layer effected by Effects

I'm trying to achieve an effect that I'm sure is possible but probably takes some advanced knowledge of Effect functionality.

Example: Let's say my Layer is just a flat image. Simple. Now I want a specific rectangle selection of that Layer image affected by the Tint effect. Is this possible? If so, how is it done?

I would look at the "Lighting Demo" in Construct. It is probably not exactly what you need, but I think this will set you down the correct path.