How do I make a powerup that doesn't respawn on death?

I want to make a powerup for my game that doesn't respawn on restarting the layout. However I just want one powerup copy to be used, rather than lots of copies used for different instances. Is there a way I can restart the layout for a death, and then not have the powerup spawn again?

If you use persist behaviour on the power up object, when it is destroyed it remains destroyed even when you return to the layout.