Is it possible to use PHP / mySQL without uploading first ?

Hi.

Is it possible to use PHP files and a mySQL database with construct 2 when running the layout inside construct 2 ( instead of uploading it to a server) ?

PHP and mySQL need to be on a server to be executed. Your game is on the client side, so it doesn't matter where it is (published or started from C2 editor).

You can download xampp to host the PHP and mySQL locally on your pc and it'll work without any limitations. (So that no server is needed to have c2 game, php, mysql)

Thank you