I've been developing my game for a while using a single event sheet and setting every parameter as "if LayoutName = "Whateverthelayoutnameis", and then having all of my events under those for each layout. While everything works fine this way, I loaded up the debugger just to play around with, and it looks like stuff that should NOT be utilizing CPU actually is (very minimal, 0.1% here or there, but it adds up rather quickly).
Is the way I'm going about this wrong? Should I have an event sheet for each layout? Or is there a better way to do a one event sheet game?