How do I Have a Layout inside of another Layout?

Is this possible?

I want to have a Main Layout that acts as a main Hub and have another Layout, that can be swap with another, to appear in the center of the Main Layout.

I would like it if I can click though the Layout in the center and click on an object behind it.

One of the reasons why we want to do this instead of having one Layout with Layers is that we are working as a group and we do not want to step over each other's work.

Thank you in advance

I don't believe this is possible, at least not as you presently envision it. There are probably work-arounds, but I am still not 100% clear on what you are trying to do.

Use layers instead.